Chronic pain is a major medical problem that is resistant to conventional medical intervention. It also causes emotional changes such as anxiety and fear. Anxiety or fear often enhances the suffering of pain. In this special meeting, we will focus on the discussions of recent progress made in the roles of supraspinal structures including cortical regions in pain and chronic pain. Furthermore, neuroscientists from synaptic plasticity and memory will provide novel knowledge of brain process of fear, anxiety. We hope that new concepts and ideas of our suffering mind will be produced during this exciting symposium.